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Research highlight

Subcellular location of signaling proteins determines cell shape

The small GTPase RhoA is best known for its ability to remodel the actin cytoskeleton of cells. To study the mechanism underlying the spatiotemporal control of RhoA activity by GEFs, single cell imaging was performed with an improved FRET sensor reporting on the nucleotide loading state of RhoA. A synthetic system (based on rapamycin induced heterodimerization) was used to show that recruitment of RhoGEF activity to the plasma membrane, but not to the Golgi apparatus, is sufficient for RhoA activation and actin polymerization. The research, carried out at Molecular Cytology (SILS-FNWI) and the van Leeuwenhoek Centre for Advanced Microscopy, was published in the journal Scientific reports.

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Molecular Cytology

The section of Molecular Cytology is located at the Swammerdam Institute for Life Sciences, part of the Faculty of Science at the University of Amsterdam. The central research theme is 'Self-organisation and signalling in living cells'. To study this we make use of the wide range of fluorescence microscopes of the van Leeuwenhoek Centre for Advanced Microscopy that is embedded in the section.

For more info about Molecular Cytology:
Prof. dr. Dorus Gadella
room C2.266
Sciencepark 904
The Netherlands
Tel: -31-(0)20-525 6259

Website: Mark Hink